Glyphosate- and ALS-resistant Palmer amaranth is our number one problem. It is wide-spread across the state and is very problematic in cotton and soybean where we have traditionally relied on glyphosate. It infests at least 70% of our cotton and soybean fields. A state-wide survey in the fall of 2010 showed that 95% of 130 populations collected on a grid sampling of the state east of the mountains had multiple resistance to glyphosate and ALS inhibitors. A paper entitled Distribution of Glyphosate- and Thifensulfuron-resistant Palmer Amaranth (Amaranthus palmeri) in North Carolina by A.H. Poirier, A. C. York, D. L. Jordan, A. Chandi, W. J. Everman, and J. R. Whitaker has been accepted by International Journal of Agronomy. ACCase- and ALS-resistant Italian ryegrass is also a serious and wide-spread problem in wheat. The only option left for control at the current time is Axiom, but the application window is very narrow and the product performs inconsistently because of the need for very timely rainfall to activate it. In some areas, the problem is bad enough that wheat is being abandoned.